After a slow start to the season, Juventus look to bounce back from their defeat at Napoli and their 2-0 loss to Lazio in the Champions League final on Sunday.
The Bianconeri are also facing the task of facing Napoli again at the Stadio Olimpico in their final Group F game of the campaign.
Napoli have scored seven goals in the group stage so far and have the upper hand at the top of Group D after taking four points from their first five matches.
The Italian champions have won the opening two meetings against Juventus, with their only loss in the competition coming in the last-16 stage in the 2015/16 season.
The win at Napolo on Saturday is the Bianconero’s first away win since a 1-0 defeat in the Serie A title decider.
Napolo’s last defeat was against AC Milan on October 13.
Juventus boss Zdenek Zeman will look to continue his winning ways after his side took their fifth straight victory over Lazio.
Zeman has made four changes to the side that won 4-1 on aggregate against Lazio last weekend, with the former Roma boss replacing Paulo Dybala and Marco Fabian, who both started.
Fabian has been out injured since the Champions Leagues clash with Sampdoria.
The Italy international made three appearances for Lazio after making his debut in the 2-2 draw with Fiorentina in October.
Juve have won two of their last three Serie A games, the only other victory coming in December’s group stage quarter-final against Torino.
Milan are without goalkeeper Gianluigi Donnarumma for the final time after he was stretchered off in the 55th minute of their 2 – 0 win at Sampdione on Saturday.
Donnarus goal was ruled out as the ball went out of bounds at the Napoli goal.
The 20-year-old has started just once this season and has scored just once.
Donni was replaced by Matteo Montolivo and he will return in the 45th minute.
Lazio’s win over AC Milan was their third in four games after a 1 – 0 victory at San Siro on September 17.
After a comfortable win at Sassuolo last weekend (4-0 win) the Biancocelesti are now in the hunt for a place in the semi-finals of the Champions league, with a match against AC Stadiale coming on Sunday (7:45pm).
Lazio have only lost once this campaign, when they were eliminated by Bologna in the Europa League in August.
The last time Lazio lost to AC Stadella was in April 2016, when the Biancolesti lost 3-1 at the Vicente Calderon.
Bologna coach Luciano Spalletti has named his side for the game, with Mario Pasalic and Andrea Pirlo making the starting line-ups.
Sampdoria are without their captain, Marco Falchetti, after he picked up a knee injury in the final seconds of the match against Bolognese.
The Rossoneri have only won two Serie A matches this season, losing at Sassuso in the quarter-finals and then beating AC Milan in the semis.
In addition to Falchetti, Lazio also have the return of Paulo Dybbala, who started against AC Nacional in the 1-1 draw on August 23.
The 30-year old has only played in two of Lazio’s last nine games and scored one goal.
Defender Marco Fassone is out with a thigh injury and Andrea Gabbiadini has returned from suspension after a thigh problem.
Vicente Calderón’s squad for the match includes a host of players from the recent Champions League winners and runners-up, but not one player from Lazio, who have lost in the previous round of the competition.
Gabbiardini, Mario Puzo, Andrea Pina, and Mario Callejon are the only Lazio players to have appeared in the Italian Cup, which is awarded to the winners of the final round of a group stage.
Napoli have started their campaign with a 1 v 1 against Torinese in the first leg of the last round of Champions League.
Napolese midfielder Edin Dzeko picked up an injury and will miss the rest of the game.
It was a poor start to Juventus’ season, with both goals coming in their first two games.
The Serie A side have been without the services of their captain and first choice right-back Giorgio Chiellini, while Lazio captain Mauro Icardi and forward Marco Verratti are also absent.
Italy coach Zdenko Matic has made three changes to his squad for Saturday’s game against